Peter Parker has been through a lot across comics, TV, movies, and games. One constant is the death of Uncle Ben, putting him on the path of heroism as he vows to use his powers responsibly. In a few adaptations and stories, ol' May kicks the bucket too, like in the Insomniac games. But she does that when he's an adult, so Pete at least gets a childhood with her. Unless you manage to time travel like RebelOrion did.